Influence of lead on activity of nitric oxide synthase in neurons and vessel smooth muscle of small intestine in rats
Kong, X.Y.; Liao, L.M.; Lei, D.L.; Huang, J.F.; Wen, X.D.
Hunan Yi Ke da Xue Xue Bao 25(2): 135-137
2000
ISSN/ISBN: 1000-5625 PMID: 12212199 Document Number: 519144
The beta-NADPH histochemical method was used to study the effect of lead on activity of nitric oxide synthase(NOS) in neurons and vessel smooth muscles of intestinal wall in rats. The results showed that the number of NOS positive neurons and fibers was decreased and degenerative changes of some NOS positive neurons were found after the lead acetate intraperitoneal injection. The activity of NOS in the vessel smooth muscles was reduced. It suggests that lead colic may be induced by reduction of NO in the neurons which innervate the gut smooth muscles.