Pharmacogenetics: role in modifying drug dosage regimens
Mah, J.T.; Wong, J.Y.; Lee, E.J.
Annals of the Academy of Medicine Singapore 29(5): 628-632
2000
ISSN/ISBN: 0304-4602 PMID: 11126699 Document Number: 518769
With the advent of new molecular biology and scientific techniques, there is better understanding of genetic polymorphisms in oxidative drug metabolism systems today. These systems are important in pharmacogenetic studies which genotype polymorphic alleles encoding drug metabolising enzymes to enable the individual's drug metabolising phenotype to be found. Once found, the knowledge can be used to tailor drug dosage regimens to an individual to maximise therapeutic efficacy and minimise adverse drug reactions (ADRs). The knowledge could also be used to optimise drug development programmes so that all the subgroups within a target population are adequately represented in clinical trails.