Malfunction of some immunologic functions in patients with obstructive sleep apnea
Sokolnicka, I.; Zieliński, J.; Skopińska-Rózewska, E.; Barcz, E.; Pływaczewski, R.; Zabuska-Jabłońska, K.
Pneumonologia i Alergologia Polska 68(5-6): 247-254
2000
ISSN/ISBN: 0867-7077 PMID: 11004863 Document Number: 517869
Hypoxia and sleep disorders may result in an impairment of immune system in patients with obstructive sleep apnea (OSA). Therefore we studied mitogenic stimulation of peripheral blood lymphocytes by PHA (1 microgram/ml) by measurement of 3H-thymidine incorporation, metabolic activity of neutrophils measured by chemiluminescence (CL), immunoglobulins (IgG, IgA and IgM) concentration in serum (radial immunodiffusion) and TNF-alpha concentration in serum (ELISA), and E-rosette tests (with theophylline) in 57 obese patients with severe OSA. In OSA patients severe impairment of f-MLP-induced granulocyte chemiluminescent activity was observed.