Approaches to prediction of gastropathy development risk due to non-steroidal antiinflammatory drugs
Alekseeva, A.V.; Murav'ev, I.V.
Terapevticheskii Arkhiv 72(5): 25-28
2000
ISSN/ISBN: 0040-3660 PMID: 11109614 Document Number: 517693
Examination of gastric secretion in rheumatoid arthritis (RA) patients and its response to sodium diclophenak and indomethacine. 46 RA patients entered the study. All of them have been long on nonsteroid antiinflammatory drugs (NAID). Two groups of patients were analysed: group 1--free of NAID gastropathy, group 2--with NAID gastropathy. pH was followed by Gastroscan system. The analysis of 24-h pH-grams in both groups when NAID were not taken showed that in NAID gastropathy acid-forming gastric function is not affected while the alkalizing function markedly declines. Indomethacine is more aggressive to upper gastrointestinal tract mucosa than sodium diclophenak. Dynamic intragastric pH-metry can prognosticate the risk of NAID gastropathy.