Some aspects of studies with oral contraceptives in Indian women
Shah, P.N.
Journal of Obstetrics and Gynaecology of India 16(4): 409-414
1966
ISSN/ISBN: 0971-9202 PMID: 12262163 Document Number: 517556
In a study of the occurrence of pregnancy after withdrawal of oral contraceptives, the following acceptor characteristics and preferences were gleaned: 1) age range was 18-39 years (average, 26.8); average total pregnancies was 3.4; average number of live children was 2.8; 50% of the women were illiterate; and 75% belonged to a per capita income group less than the national average. 4 compounds were studied comparatively to determine side effects (1 sequential and 3 combined). The most radical difference in preparation effects was in menstrual flow changes. Anovlar decreased the flow most significantly and flow did not change after cessation in 26.9% of Anovlar users compared with users of the sequential tablets in which flow was hardly decreased and did not change after cessation in 68% of women. A series of liver function studies showed that SGOT and SGPT values were altered by use of oral contraceptives (P .001). Information on 66 women who withdrew medication after 13 or more cycles showed that 57.5% conceived within the first 6 months, with the maximum number of pregnancies occurring in the first withdrawal cycle. Overall, all 4 compounds were virtually 100% effective, showed minimal side effects, and had high acceptability in this population.