Clinical study of the month. The HOPE study, a two-by-two factorial clinical trial with contrasted results
Scheen, A.J.
Revue medicale de Liege 55(2): 121-124
2000
ISSN/ISBN: 0370-629X PMID: 10769584 Document Number: 516638
The results of the HOPE ("Heart Outcomes Prevention Evaluation") study, recently published in the New England Journal of Medicine, demonstrated a highly significant cardiovascular protection by an angiotensin converting enzyme inhibitor, ramipril at a dose of 10 mg/day, after a mean follow-up of 4.5 years, but not of vitamin E supplements at a dose of 400 UI/day in high-risk patients (> 55 years old) who had evidence of vascular disease (secondary prevention) or combined diabetes mellitus and another cardiovascular risk factor (primary prevention).
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