Effect of cycloferon on the evolution of cervical and vaginal cancer in mice
Zabezhinskiĭ, M.A.; Zarinova, E.A.; Popovich, I.G.; Kovalenko, A.L.; Anisimov, V.N.
Voprosy Onkologii 46(4): 433-437
2000
ISSN/ISBN: 0507-3758 PMID: 11147419 Document Number: 516562
7,12-dimethylbenz(a)anthracene (DMBA) was given by tampon intravaginally to 198 mice CBA (9 groups), twice a week, for 2 months, to induce cervical and vaginal tumors. Cycloferon (CF)--an interferon inductor--was injected in study group animals subcutaneously and/or introduced into the vagina by smear, in 2-month courses. CF was given during DMBA treatment or after it. Controls were injected saline solution, sc, and/or received placebo smears, i.v. The experiment was run for 6 months. Tumor incidence in controls was 35-70%. Carcinogenesis tended to slow down when CF was given during DMBA treatment. Neoplasia was found in 38-57%. More marked anticarcinogenic effect was registered in animals receiving CF on termination of DMBA application: tumor frequency dropped to 29-41%, with malignant tumor number significantly reduced.