Experimental study of abnormal cell proliferation and differentiation in rat tongue carcinogenesis induced by 4NQO
Liu, X.K.; He, R.G.; Chen, W.T.; Zhang, Z.Y.; Zhou, C.T.; Zhou, X.J.
Shanghai Kou Qiang Yi Xue 9(2): 67-69
2000
ISSN/ISBN: 1006-7248 PMID: 15014809 Document Number: 516461
To clarify the phenotypic characteristics of abnormal cell proliferation and differentiation in oral carcinogenesis. The expressions of gp230, a marker of epithelium cell differentiation, and proliferating cell nuclear antigen (PCNA) in rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide (4NQO) were detected by LSAB immunohistochemical staining. With the progress of oral carcinogenesis abnormal proliferation and differentiation patterns were indicated by reduced expression of gp230 and increased expression of PCNA. Oral carcinogenesis is the result of mucosa epithelium cell aberrant proliferation and differentiation.