Do cognitive deficits in depressive disorders remit?
Frasch, K.; Bretschneider, S.; Bullacher, C.; Hess, R.; Wittek, R.; Neumann, N.U.
Psychiatrische Praxis 27(6): 291-295
2000
ISSN/ISBN: 0303-4259 PMID: 11050736 Document Number: 516177
The importance of cognitive deficits concerning schizophrenics is well-known. Much less material of that kind has been collected from patients with affective disorders, which was the aim of this clinical study. Inclusion criterions were in- and outpatients with affective disorders (ICD-10: F31-F33) aged < 61. The clinical status was determined by use of the HAMD-21, the subjects were examined by means of standardised computerised cognitive performance tests (CGT-[M], DAUF). The results were correlated with the HAMD and the psychiatric pharmacotherapy. In each of the three subtests the heavily depressive group (HAMD > 24, n = 14) came off significantly (Mann-Whitney-U-Test, p < 0.05) worse than the remitted group (HAMD < or = 8, n = 18) while 8 of the 18 remitted patients showed pathological results in the CGT-(M). Only patients who took tranquilizers performed significantly worse than patients without such medication (p < 0.05). In some cases of affective disorders, a "cognitive residual syndrome" persists which is rather part of the disease than pharmacotherapy-associated.