Glucocorticosteroids in bacterial endocarditis: is it beneficial or harmful?
Tiurin, V.P.
Terapevticheskii Arkhiv 72(6): 60-63
2000
ISSN/ISBN: 0040-3660 PMID: 10900654 Document Number: 516061
Analysis of results of treatment of infectious endocarditis (IE) with glucocorticosteroids in combination with antibiotics. 128 IE patients received antibiotics (control group). Glucocorticosteroids were added to antibiotics in 44 IE patients (study group). Valvular replacement, congestive heart insufficiency, thromboembolic complications, suppression of cellular and humoral immunity occurred more frequently in patients of the study group. It was found that glucocorticosteroids affect IE negatively, especially in the dose 30 mg/day and higher. Glucocorticosteroids are indicated in allergic reactions to the antibacterial drugs, severe renal damage (proteinuria < 1 g/l), myocardial defects; contraindicated in non-eradicated IE causative agent, in recurrent IE.