Incipient perisinusoidal fibrosis in an adult patient with Dubin-Johnson syndrome
Kuvandzhiev, G.K.; Zaprianov, Z.N.; Dikov, D.I.
Folia Medica 42(1): 62-65
2000
ISSN/ISBN: 0204-8043 PMID: 10979180 Document Number: 515688
The present paper describes a rare case of incipient perisinusoidal fibrosis of perihepatocellular type occurring in the Dubin-Johnson syndrome in a 63-year-old patient operated on six months previously for chronic calculous cholecystitis. The source of collagen formation was the activated sinusoidal Ito cells. Excluding chronic virus hepatitis and reactive cholecystic hepatitis, we believe that the fibrosis in this patient can be associated with the relatively old age of the patient and the duration of the disease.