Evaluation on the effect of Benazepril for hypertension through postmarketing surveillance
Cao, W.; Li, L.; Hu, Y.; Zhan, S.; Li, X.; Li, P.; Wu, T.; Li, J.; Wang, T.
Zhonghua Liu Xing Bing Xue Za Zhi 21(3): 190-193
2000
ISSN/ISBN: 0254-6450 PMID: 11860782 Document Number: 515416
To evaluate the efficacy and safety of Benazepril used among the essential hypertensives. 1 831 essential hypertensive patients aged 35 to 75 were randomly selected from a community and followed for 18 months. The level of blood pressure, status of taking Benazepril and side effects were sequencially collected. 1/3 of the patients had taken antihypertensive drug before the study and the rate of compliance was over 96%. The effective rate of Benazepril was 73.6% at three months and increased to 84.7% at 18 months. Comparing with the baseline data, SBP and DBP declined 10.8 mmHg and 6.7 mmHg respectively. The rate of side effect was 22.7%. Cough was most commonly seen among side effects. The peak of first recording on side effect occurred at three months including 60% of them mild. Results showed that Benazepril had good efficacy and safety for the essential hypertension patients in a long-term observation.