Clinical and genetic heterogeneity of rheumatoid arthritis
Klimiuk, P.A.; Weyand, C.M.; Sierakowski, S.; Goronzy, J.J.
Postepy Higieny i Medycyny Doswiadczalnej 54(6): 845-853
2000
ISSN/ISBN: 0032-5449 PMID: 11227380 Document Number: 514949
The diagnostic category of rheumatoid arthritis, a syndrome of chronic inflammatory disease of the synovial membrane and of extraarticular tissues, covers a broad spectrum of clinical phenotypes. Here we propose that distinct combinations of disease risk genes produce heterogeneity of rheumatoid disease. Recognition of this genetic and clinical heterogeneity has immediate implications as it provides the opportunity to develop selective therapies for the different variants of disease.
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