Measurements for assessing environmental exposures to children using small amounts of serum and urine: state-of-the-art
Dimandja, J.M.; Grainger, J.; Patterson, D.G.; Turner, W.E.; Needham, L.L.
Journal of exposure analysis and environmental epidemiology 10(6 Pt 2): 761-768
2000
ISSN/ISBN: 1053-4245 PMID: 11138668 Document Number: 514584
This paper addresses the recent advances in gas chromatographic (GC)-based instrumentation for the analytical determination of environmental toxicants using small samples. One-dimensional GC/time-of-flight mass spectrometry (TOFMS) and comprehensive two-dimensional GC (GCxGC) are shown to drastically improve sample component resolution, sensitivity and overall analytical throughput. A presentation of the concepts behind the new state-of-the-art, and results highlighting the advantages of the emerging technologies are presented.