The role of PKC isoforms in tumorigenicity and apoptotic cell death
Rybczyńska, M.; Ksiazek, K.; Kaczmarek, J.
Postepy Higieny i Medycyny Doswiadczalnej 54(6): 777-796
2000
ISSN/ISBN: 0032-5449 PMID: 11227376 Document Number: 513559
Protein kinase C comprises a family of at least 13 distinct serine/threonine kinase isoenzymes that have important actions in transmembrane signal transduction pathways and have been reported to regulate cell proliferation, differentiation, cell-to-cell interaction, cytoskeletal functions, gene transcription, apoptosis and drug resistance. The results of investigations show differential redistribution isoenzymes in each organ and their specific activity in determined diseases.