Morphometrical study on the development of the trisomy-18 with cleft palate and euploid mice
Cai, Z.; von Domarus, H.; Engel, E.
Zhonghua Kou Qiang Yi Xue Za Zhi 35(5): 371-373
2000
ISSN/ISBN: 1002-0098 PMID: 11780248 Document Number: 512755
To quantitatively compare the whole body, the lateral maxillofacial profile in Ts18 foetuses with cleft palate (Ts + CP) and euploid foetuses in order to answer the question whether this animal model is associated with maldevelopment or hypoplasia of the craniomaxillofacial region. Sixty female Hanmice and 11 male mice with the Rb(2.18) 6Rma and Rb(1.18) 10Rma chromosomes were used to generate 569 living foetuses. Of these, 52 pairs Ts + CP and euploid foetuses were selected according to about equal body weight, and used in gross morphometric study. Ts + 18 foetuses had greater body flexion, a significant maxillary and mandibular retrusion, also mandible in Ts + CP foetuses were smaller than in euploids without cleft. This animal model of congenital cleft palate developed hypoplasia of the maxilla and mandible.