First report of lymphatic mapping with isosulfan blue dye and sentinel node biopsy in cervical cancer
Medl, M.; Peters-Engl, C.; Schütz, P.; Vesely, M.; Sevelda, P.
Anticancer Research 20(2b): 1133-1134
2000
ISSN/ISBN: 0250-7005 PMID: 10810409 Document Number: 512661
Background: Sentinel lymph node status provides important information about the status of the regional nodes in various malignant tumors. Our report describes a method of identifying the sentinel lymph nodes in cervical cancer. Patients and Methods: In three cases of early cervical cancer, isosulfan blue dye was injected paracervically into each lateral fornix immediately before surgery. Results: In all cases we identified two to three blue stained (sentinel) lymphnodes located either at the iliac artery or in the obturatory space. The blue colored nodes were positive for disease, all other pelvic lymphnodes removed were negative. Conclusions: Our findings demonstrate that preoperative lymphatic mapping with vital blue dye is an easy to perform technique to visualize sentinel Iymph nodes in cervical cancer. Sentinel lymph node status may be representative of the pelvic lymph node status in cervical cancer and thus could provide important information for further treatment.