Childhood acute myeloblastic leukemias. Report of 21 cases
Laatiri, M.A.; Chehata, S.; Amouri, A.; Bouaouina, N.; Chatti, S.; Saad, A.; Ennabli, S.
La Tunisie Medicale 78(3): 167-171
2000
ISSN/ISBN: 0041-4131 PMID: 11026819 Document Number: 512345
Between 1989 and 1996, 21 cases with acute non lymphoblastic leukemia (11 males and 10 females) were diagnosed in our institution. Median age was 9 years (range, 2-15 years). Leukocyte count was more than 50,109/l in 47% of cases. According to the French-American-British (FAB) criteria, 7 cases were classified M1, 10 cases were classified M2, 1 classified M4Eo and 3 classified M5. All patients were treated with "7 + 3" protocol and complete remission was achieved in 17 cases (80%), 2 cases (10%) failed to respond and 2 (10%) died during induction. Relapse was observed in 15 cases. The 3-year survival rate was 20% and the relapse-free-survival rate was 12% confirming the worse prognosis of this leukemia when treated with standard chemotherapy.