Prognosis of individual survival in animals with fatal and non-fatal tumors
Krut'ko, V.N.; Smirnova, T.M.; Anisimov, V.N.
Voprosy Onkologii 45(5): 546-549
1999
ISSN/ISBN: 0507-3758 PMID: 10629715 Document Number: 511684
Cohort analysis of life span in a uniform LIO rat population established a correlation between death cause and age-related death force parameters. It also demonstrated certain sex-related differences involved. The life span of males which had tumors at the time of death, whatever the real cause of death, was significantly longer than that in tumor-free animals. The life span of tumor-free females and those which died from cancer was shorter while the longest-surviving group bore non-fatal tumors. It is suggested that prognosis of individual survival be based on a combination of traditional procedures of mathematical evaluation of population mortality rates and complex assessment of individual health. This approach envisages formation of cohorts characterized by maximum differences in aging dynamics.