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Immunological methods in the diagnosis of monoclonal gammopathies. the prognostic impact of the immunological data

Baldea, L.; Cucuianu, A.; Cristea, A.

Romanian Journal of Internal Medicine 37(3): 217-225

1999

ISSN/ISBN: 1220-4749
PMID: 15532300
Document Number: 511538
Immunological data are extremely important for the diagnosis of monoclonal gammopathies (MG). During the 1977-1998 period, 160 MG cases were diagnosed in our laboratory. Out of the 130 multiple myeloma (MM) cases, 70 (53.85%) met the strictly immunological criteria; in the rest of the cases, the immunological data had to be corroborated with the bone marrow cytology and bone X-ray data. We tried to assess retrospectively the prognostic impact of the immunological data on the 60 cases that were treated and followed at the Hematology Dept. of the Cancer Institute, Cluj. The following parameters were found to have a favorable prognostic impact on survival: IgG monoclonal component, kappa light chains, response to therapy with plateau phase achievement, Salmon Durie stages I and II at diagnosis.

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