A comparative study of the efficacy of pharmacological agents in regulating the level of NADPH in the hepatocytes in an acute lesion
Inoiatova, F.K.; Khakimov, Z.Z.
Eksperimental'naia i Klinicheskaia Farmakologiia 62(3): 50-52
1999
ISSN/ISBN: 0869-2092 PMID: 10439950 Document Number: 510489
Experiments on mice with acute toxic damage to the liver induced by thioacetamide (200 mg/kg) demonstrated inhibited activity of enzymes glucose-6-phosphate dehydrogenase (G-6-PDH), NADPH-dependent isocitrate dehydrogenase and malate dehydrogenase in the hepatocyte mitochondrial and microsomal-cytosol fractions. Pharmacotherapy with membranostabilizers and cytochrome P-450 inducers activated the enzymes under study, the degree of activation depended on agents used.