Clinical spectrum of adult onset spontaneous primary hypothyroidism
Zargar, A.H.; Laway, B.A.; Bashir, M.I.; Masoodi, S.R.; Wani, A.I.; Salahuddin, M.
Saudi Medical Journal 20(11): 870-873
1999
ISSN/ISBN: 0379-5284 PMID: 27645012 Document Number: 510450
Objective: Hypothyroidism is a common entity in this part of the world. The objective of this study was to analyse the clinical and endocrine/biochemical data of 250 subjects with spontaneous primary hypothyroidism. Methods: Subjects 18 years or older who had thyroid stimulating hormone value of >10 mIU/ml were studied for clinical and biochemical features. Results: There was a female predominance, female to male ratio being 3.2: 1. There was a less frequent occurrence of thyromegaly and the patients were relatively younger. Conclusions: Predominant occurrence in females and less frequent occurrence of thyromegaly suggest a possible autoimmune atrophic thyroiditis as the most probable etiology of spontaneous primary hypothyroidism.