Reversal of drug resistance in bacteria and tumor cells. (Drug research based on computer-predicted activity)
Molnár, J.
Orvosi Hetilap 140(39): 2155-2160
1999
ISSN/ISBN: 0030-6002 PMID: 10533378 Document Number: 510069
This paper present a short overview on the new perspectives in drug-design against drug resistance phenomena focusing on the infectious antibiotic resistance of bacteria. The role of plasmids in resistance of bacteria, the mode of transmissions were analyzed in details. The elimination of plasmids--the genetic basis of bacterial resistance located extrachromosomally--was studied systematically with several heterocyclic compounds. Correlations were analyzed between the anti-plasmids++ effects and chemical structure of tricyclic compounds in quantitative structure activity relationship (QSAR) studies. A hypothesis was presented to exploit the analogous mechanisms of multidrug resistance in bacterial and cancer cells by inhibiting the action of drug exporter proteins in the presence of compounds synthetized on the basis of computer aided drug design.