Transport of fluid and solutes in the body II. Model validation and implications
Gyenge, C.C.; Bowen, B.D.; Reed, R.K.; Bert, J.L.
American Journal of Physiology 277(3): H1228-H1240
1999
ISSN/ISBN: 0002-9513 PMID: 10484445 Document Number: 509843
A mathematical model of short-term whole body fluid, protein, and ion distribution and transport developed earlier 300 mosmol/l. Good agreement between the model predictions and the experimental data was obtained with respect to the trends and magnitudes of fluid shifts between the intra- and extracellular compartments, extracellular ion and protein contents, and hematocrit values. The model is also able to yield information about inaccessible or difficult-to-measure system variables such as intracellular ion contents, cellular volumes, and fluid fluxes across the vascular capillary membrane, data that can be used to help interpret the behavior of the system. Reprinted by permission of the publisher.