The effect of polikatan on the ototoxic action of kanamycin
Spasov, A.A.; Lobzov, M.S.; Sanzharovskaia, N.K.; Kozhevnikova, E.V.; Kuzubova, E.A.
Eksperimental'naia i Klinicheskaia Farmakologiia 62(4): 65-66
1999
ISSN/ISBN: 0869-2092 PMID: 10513342 Document Number: 509322
Experiments on guinea pigs demonstrated that preliminary injection of polycatan (standardized magnesium solution containing the mineral bischofite) into the parotid region by means of electrophoresis reduces the ototoxic effect of the aminoglycoside antibiotic kanamycin. Polycatan prevents kanamycin-induced degenerative changes of the hair cells found in the labyrinth of the internal ear and improves the local blood flow.