Study of Cyfra 21-1 as a new tumor marker for the diagnosis of epidermoid carcinoma of the head and neck
González Sánchez, E.; López-Ríos Velasco, J.; Calvo Boizas, E.; García-Talavera Fernández, J.R.; Martín Ro-dríguez, M.; Muñoz Herrera, A.; Del Cañizo Alvarez, A.
Acta Otorrinolaringologica Espanola 50(2): 85-89
1999
ISSN/ISBN: 0001-6519 PMID: 10217679 Document Number: 509072
Serum concentrations of Cyfra 21-1, a soluble cytokeratin fragment, were evaluated in 157 healthy patients, 66 patients with benign ear, nose or throat disease, and 102 patients with untreated epidermoid carcinoma of the head and neck. The technique had a sensitivity of 53.9% and specificity of 98.4% for a cutoff value of 1.5 ng/ml. Cyfra 21-1 levels differed significantly with tumor location (p < 0. 005) and tumor stage (p < 0.005), but not with the degree of histological differentiation.