Programmatic implementation of blastocyst transfer in a university-based in vitro fertilization clinic: maximizing pregnancy rates and minimizing triplet rates
Grifo, J.A.; Flisser, E.; Adler, A.; McCaffrey, C.; Krey, L.C.; Licciardi, F.; Noyes, N.; Kump, L.M.; Berkeley, A.S.
Fertility and Sterility 88(2): 294-300
2007
ISSN/ISBN: 0015-0282 PMID: 17531995 DOI: 10.1016/j.fertnstert.2006.10.005Document Number: 507929
To assess whether the use of extended embryo culture can reduce the incidence of high-order multiple gestations, a retrospective analysis of 7,418 fresh ETs performed in a university-based IVF clinic from 1997-2003 was conducted, comparing program results before and after institution of a protocol to select patients for extended culture of in vitro fertilized embryos. The incidence of triplet pregnancies was significantly reduced in patients at highest risk for high-order multiple gestations, i.e., those at <35 years of age (16.8% versus 6.8%), those at 35-37 years of age (13.0% versus 5.6%), and recipients of donated oocytes (11.2% versus 4.5%).
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