The action of ADP ribose on the mechanical and bioelectrical activity of the frog heart
Sosulina, L.I.; Sukhova, G.S.; Chudnyĭ, M.N.; Ashmarin, I.P.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 85(4): 508-514
1999
ISSN/ISBN: 0869-8139 PMID: 10513384 Document Number: 507419
In the frog isolated heart, cyclic perfusion of ADP-ribose induced a dose-dependent decrease in the heart rate and the contraction force, a decrease in the AP duration as well as in the rate of rise in the sinus node. It also shortened the atrial AP and exerted no significant effect upon multicellular ventricular preparations. In conditions of systemic administration in unanesthetised frogs, the ADP-ribose induced a reversible increase in the heart rate due, probably, to a sympathetic effect.