Radiographic, biomechanical, and pathologic effects of hemoglobin glutamer-200 in dogs undergoing cemented total hip arthroplasty
Braden, T.D.; Tvedten, H.W.; DeCamp, C.E.; Turner, T.M.; Hughes, G.S.; Rentko, V.T.
American Journal of Veterinary Research 60(11): 1337-1340
1999
ISSN/ISBN: 0002-9645 PMID: 10566804 Document Number: 507277
Nine adult dogs were anaesthetized, and 15% of the blood volume was removed. Simultaneously, lactated Ringer's solution was infused, and 6 dogs were given haemoglobin glutamer (1 g/kg body weight, i.v.). Unilateral total hip replacement was performed. Limb use was assessed visually, and force-plate and radiographic evaluations were performed before and 8 weeks after surgery. Eight weeks after surgery, dogs were killed, PM was performed, and prosthetic component pullout forces were determined. There was no significant difference between treated and control dogs in regard to biomechanical (visual assessment of gait, force-plate analysis, femoral and acetabular component pullout forces) and pathological evaluations (physical examination, complete blood count, serum biochemical analyses, PM findings and histological evaluations). Radiographic signs of loosening of the femoral component were seen in 4 dogs treated with haemoglobin glutamer. Administration of haemoglobin glutamer as a blood substitute did not appear to have any deleterious effects in dogs undergoing total hip arthroplasty.