The possibility of using Daphnia magna as an alternative test object for evaluating the receptor selectivity of cholinotropic substances

Tonkopiĭ, V.D.; Kosmachev, A.B.; Zagrebin, A.O.; Fil'ko, O.A.; Tonkopii, V.D; Kosmachev, A.B; Zagrebin, A.O; Fil&apo; ko, O.A

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The possibility of using Daphnia magna as an alternative test object for evaluating the receptor selectivity of cholinotropic substances

Tonkopiĭ, V.D.; Kosmachev, A.B.; Zagrebin, A.O.; Fil'ko, O.A.

Eksperimental'naia i Klinicheskaia Farmakologiia 62(6): 23-25

1999

ISSN/ISBN: 0869-2092

PMID: 10650521

Document Number: 506637

The results of study of the selectivity of the effects of cholinonegative and cholinopositive agents obtained on Daphnia magna hydrobionts were compared with the results of investigations on rats. This allowed Daphnia to be recommended as an alternative test object for studying the selectivity of the effect of cholinotropic agents in relation to some subtypes of muscarine receptors in an intact organism.