Non-fatal clozapine (LEPONEX) intoxication with toxicokinetic evaluation
Bedry, R.; Deschamps, L.; Pehourcq, F.; Moore, N.; Pillet, O.; Favarel-Garrigues, J.C.
Veterinary and Human Toxicology 41(1): 20-22
1999
ISSN/ISBN: 0145-6296 PMID: 9949479 Document Number: 506570
A 29-y-old male attempted suicide with 3000 mg clozapine, 150 mg zopiclone, alprazolam and unknown quantities of alcohol. He was admitted in a deep hypotonic coma with respiratory depression, inhalation pneumonia and vascular collapse. Symptomatic treatment involved mechanical ventilation, vascular filling and antibiotics. The patient was discharged from the Intensive Care Unit 72 h after the suicide attempt with no sequelae. To detect and quantify clozapine in plasma, high-pressure liquid chromatography showed a 4 h absorption phase and a peak serum concentration of 5200 ng/ml. Three successive elimination t1/2 values of 38, 24 and 13 h were calculated.