D-dimer after delivery in uncomplicated pregnancies
Ghirardini, G.; Battioni, M.; Bertellini, C.; Colombini, R.; Colla, R.; Rossi, G.
Clinical and Experimental Obstetrics and Gynecology 26(3-4): 211-212
1999
ISSN/ISBN: 0390-6663 PMID: 10668159 Document Number: 505153
D-dimer is now widely used as a coagulation marker. During pregnancy the D-dimer level increases until term even in uncomplicated pregnancies. The aim of the study was to establish the D-dimer immediately after delivery in uncomplicated pregnancies. A rapid immunoturbidimetric assay for D-dimer determination was employed in 100 consecutive deliveries. D-dimer level increased significantly in all women after delivery (increase from 1 to more than 10 times over the normal range). An increase in fibrinolysis is associated with pregnancy and delivery, and D-dimer level must be interpreted only in association with other clinical, laboratory and instrumental methods when pathological conditions (e.g. pulmonary embolism, deep vein thrombosis or disseminated coagulation) are suspected.