The effects of L-arginine in chronic pain syndromes
Danilova, E.I.; Grafova, V.N.; Kukushkin, M.L.; Zinkevich, V.A.
Eksperimental'naia i Klinicheskaia Farmakologiia 62(4): 11-13
1999
ISSN/ISBN: 0869-2092 PMID: 10513328 Document Number: 504600
The effect of L-arginine in long-term parenteral administration was studied on a model of neuropathic pain syndrome and adjuvant arthritis. L-arginine produced a preventive and therapeutic effect in the neuropathic pain syndrome. It weakened the development of adjuvant arthritis for the period of its administration. The factor underlying the effect of L-arginine is its double action as a precursor of nitrous oxide and kiotorphin, an endogenous antinociceptive dipeptide.