The combination therapy of clarithromycin and sparfloxacin for pulmonary Mycobacterium gordonae infection
Tomiyama, Y.; Maesaki, S.; Yong, B.; Higashiyama, Y.; Miyazaki, Y.; Tomono, K.; Tashiro, T.; Kohno, S.
Kekkaku 74(5): 457-461
1999
ISSN/ISBN: 0022-9776 PMID: 10386036 Document Number: 504444
Seventy years old woman had fever and hemosputum at May 1997. She was diagnosed as mycobacteriosis because of the positive acid fast bacilli smear from sputum. Mycobacterium gordonae was isolated from sputum, gastric juice, and bronchial aspirate. The combination therapy of isoniazid, rifampicin, ethambutol, and clarithromycin was administrated; however, M. gordonae was not eradicated from sputum. Sparfloxacin was administered instead of isoniazid based on the result of drug susceptibility test. The smear became negative and M. gordonae was eradicated from sputum one month after the initiation of treatment with the combination of clarithromycin and sparfloxacin.