Mixed follicular and parafollicular thyroid carcinoma
Vitri, P.; Galimberti, A.; De Pasquale, L.; Vago, L.; Boldorini, R.; Bastagli, A.
Journal of Experimental and Clinical Cancer Research Cr 18(4): 567-569
1999
ISSN/ISBN: 0392-9078 PMID: 10746987 Document Number: 503169
A rare case of mixed follicular-parafollicular thyroid carcinoma which occurred in a 50-year-old man, is reported. The ultrastructural aspects of the tumor showed: a biphasic growth pattern with microfolliculi and solid areas; the coexpression of thyroglobulin and calcitonin antigens in the same follicle-like structures; the presence of neuroendocrine granules, microvilli and intracytoplasmic canaliculi bordered by microvilli. These characteristics lead us to a diagnosis of mixed follicular-parafollicular thyroid carcinoma.