Biochemical mechanisms of thoracic fibrosis development after pneumonectomy in patients operated for progressive pulmonary tuberculosis
Kaminskaia, G.O.; Grigor'eva, E.V.; Testov, V.V.
Problemy Tuberkuleza 1: 51-54
1999
ISSN/ISBN: 0032-9533 PMID: 10199187 Document Number: 502498
Forty three patients undergone pulmonectomy/pleuropulmonectomy were studied 1-3 days to 1.5 months after surgery. The content of total protein (TP), fibronectin (FN), medium-weight molecules, fibrinogen and fibrin degradation products (FFDP). In the absence of complications within the first 3 weeks after surgery, exudate was concentrated along with intensive cavitary proteolytic clearance, then there was deposited fibrin lysis concurrently with increased local FN synthesis. The magnitude of the two latter processes was directly relate to the rates of residual cavitary fragmentation and obliteration. In patients with empyema, fluid drainage from the residual cavity and exudate was impaired in the early postoperative period and the exudate was characterized by very low concentrations of TP, FN, FFDP. Subsequently, the phenomena of exudate dilution remained, which was associate with a decrease in the rate of proteolytic processes and a slow increase in local FN synthesis.