The effect of cytochrome c on the myocardium during reperfusion
Boiarinov, G.A.; Iakovlev, A.I.; Teziaeva, S.A.; Mukhina, I.V.; Boiarinova, L.V.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 4: 20-25
1999
ISSN/ISBN: 0031-2991 PMID: 10598459 Document Number: 501775
Experimental and clinical trials have shown high effectiveness of cytochrome c (0.5 mg/kg) in prevention of reperfusion myocardial disorders in cardiosurgical patients. Cytochrome c inhibits development of myocardial ischemic contracture, depression of coronary circulation, activation of lipid peroxidation. It reduces myocardial consumption of oxygen and promotes earlier restoration of fatty acids metabolism under lower glucose consumption by the heart muscle. By correction of myocardial metabolism, the drug suppresses fermentemia in early reperfusion.