Cytomegalovirus infection and glomerulonephritis
Semidotskaia, Z.D.; Artemova, S.N.
Likars'ka Sprava 4: 77-83
1999
ISSN/ISBN: 1019-5297 PMID: 10476650 Document Number: 501569
A total of 56 patients were studied with different forms of glomerulonephritis (GN). Of these, 15 subjects presented with acute, 41--chronic form of GN. The control group was 10 essentially healthy subjects. In the GN patient group, IgG to CMV was identifiable in 68 percent of patients, IgM--in 54 percent; there were only 20 percent of those demonstrating immunoglobulins to CMV among healthy subjects. CMV infection was most common among patients with nephrotic and latent forms of ChGN. Clinically, the infected patients showed a marked proteinuria, hematuria, and imbalance in the system of immunity manifested by a rise in the number of T-helpers, reduction in T-suppressors, IgG, activity of complement and system of phagocytosis.