Benign epithelial cyst of the spleen with a high production of carbohydrate antigen 19-9
Ishibashi, R.; Sakai, T.; Yamashita, Y.; Maekawa, T.; Hideshima, T.; Shirakusa, T.
International Surgery 84(2): 151-154
1999
ISSN/ISBN: 0020-8868 PMID: 10408287 Document Number: 501349
A rare case of an epithelial splenic cyst showing a high production of the carbohydrate antigen 19-9 (CA19-9) is presented. A 19-year-old female with high fever and loss of appetite was diagnosed as having a splenic cyst. Laboratory data revealed unusually elevated serum levels of both CA19-9 and CA125. The histological diagnosis was an epithelial splenic cyst, and immunohistochemically the wall of the splenic cyst was strongly positive for CA19-9 and slightly positive for both CA125 and CEA. Fluid in the splenic cyst contained quite high levels of CA19-9, CA125 and CEA. After splenectomy, the serum levels of CA19-9 and CA125 gradually decreased. These findings suggested that the splenic cyst produced CA19-9, CA125 and CEA. And with very high levels of CA19-9 and CA1 25 in the cyst, some had entered into systemic circulation.