Rothmund-Thomson syndrome with herpes encephalitis
Ito, T.; Tokura, Y.; Moriwaki, S.; Yasuda, K.; Ohnishi, A.; Furukawa, F.; Yamaizumi, K.; Takigawa, M.
European Journal of Dermatology Ejd 9(5): 354-356
1999
ISSN/ISBN: 1167-1122 PMID: 10417436 Document Number: 500553
A 4-year-old Japanese boy with Rothmund-Thomson syndrome suffered from severe herpes encephalitis at 5 months of age. The serum level of immunoglobulin G was low and the responsiveness of peripheral blood mononuclear cells to bacterial superantigens was poor. It was suggested that these immunological abnormalities, possibly associated with Rothmund-Thomson syndrome, led to severe infection with herpes simplex virus in our patient.