Experimental study on the osteoradionerosis of jaw model of dogs with vascular corrosion casting
Xie, X.; Qiu, W.; Yuan, W.
Zhonghua Kou Qiang Yi Xue Za Zhi 34(1): 9-12
1999
ISSN/ISBN: 1002-0098 PMID: 11776542 Document Number: 500260
To study pathologic alterations of mandibular microvascular system in osteoradionecrosis of jaws (ORNJ) in order to disclose its pathologic mechanism. The right maxillofacial regions of 10 dogs were exposed to cobalt-60 radiation with a total dose of 60-80 Gy and dental extraction were performed at 3, 6 months after radiation. The ORNJ was diagnosed by gross observation, X-ray film and histopathologic examination. Then, the vascular corrosion castings of jaws were implemented and investigated. At 12 months after radiation, 7 cases of ORNJ occured. It was discovered on the casting specimen that the continuity of inferior alveolar arteries remained intact except one case where the artery was obliterated due to lesion involvement. There were defects of vascular networks in the necrotic area with irregular capillaries proliferating in the periphery of lesions and around the inferior alveolar arteries, where x-ray examination showed new bone formation. Based on the experimental evidences, a new concept of pathogenesis of ORNJ is put forward: following the formation of "3-hypo" structures, local trauma-repairing process might induce capillary proliferation which bring about a large amount of mitotic death of endotheliocytes, the microcirculation failure takes place leading to ORNJ eventually.