Diagnosis and treatment of endodermal sinus tumor of the vagina
Shen, K.; Huang, R.; Lang, J.
Zhonghua Fu Chan Ke Za Zhi 34(2): 105-107
1999
ISSN/ISBN: 0529-567X PMID: 11263194 Document Number: 498967
To describe the clinical characteristics and the role of chemotherapy in endodermal sinus tumor of the vagina. Two patients with endodermal sinus tumor of the vagina were presented focusing on the clinical manifestations and outcome of the chemotherapy. Patient's age was quite young, 2 and 3 years old respectively. Vaginal bleeding and a polypoid and fragile tumor of the vagina were main clinical features. Elevated serum alpha-FP was found before chemotherapy and dropped dramatically to normal if the tumor was sensitive to chemotherapy. Diagnosis was made by pathology and alpha-FP immunohistochemical staining. Both two patient was well responded to cisplatin vincristine bleomycin (PVB) and cisplatin etoposide bleomycin (PEB) chemotherapy. Clinical and pathological complete remission was obtained after 2-3 courses of chemotherapy without radical surgery and radiotherapy. Endodermal sinus tumor of vagina in infant was very sensitive to the chemotherapy. Serum alpha-FP was very useful in diagnosis and monitoring of the disease.