Bat feces as an indoor allergen
Alonso, A.; Irañeta, S.G.; Rodríguez, S.M.; Scavini, L.M.; Rodríguez, S.R.
Journal of Investigational Allergology and Clinical Immunology 8(6): 365-369
1998
ISSN/ISBN: 1018-9068 PMID: 10028484 Document Number: 497573
We have demonstrated in an animal model (specific IgG) as well as in atopic patients suffering from rhinitis/asthma (specific IgE) that bat feces have antigenic properties. A single peak with high glycoprotein content was obtained by chromatography, while SDS-PAGE revealed several proteins between 29 and 116 kDa which showed immune serum blotting at 43.6 and 66 kDa. Positive specific skin tests with bat feces and IgE-RAST anti-bat feces were detected in atopic patients living in tall buildings and old houses in Buenos Aires. As bat feces did not cross-react with bat epithelium, studies evaluating rat serum and epithelium and pigeon feces in order to analyze the role of bat serum proteins, such as IgA, are encouraged.