Changes in Hematologic Values During Infection of New World Monkeys With Plasmodium falciparum and P. vivax
Galland, G..Gale.; Morris, C.L..; Sullivan; Roberts, J.M..; Collins, W.E..
Contemporary Topics in Laboratory Animal Science 37(5): 86-88
1998
ISSN/ISBN: 1060-0558 PMID: 12456140 Document Number: 497313
Owl (Aotus sp.) and squirrel (Saimiri sp.) monkeys are used frequently in malaria vaccine trials, during which the animals are monitored daily for parasitemia and general well-being. Every 2 weeks, blood samples are taken, and hematology and chemistries are performed. We examined 97 cases of malarial infection in owl and squirrel monkeys, whose parasitemia increased by. 22,000 parasites/uL daily during a 14-day interval. After malaria challenge, unprotected animals had significant changes in hematologic values. These changes could not be completely attributed to the increase in the parasite counts.