Tumour necrosis factor alfa and glucose levels in sera of mice infected with coxsackie B4 and A7 viruses
Bopegamage, S.A.; Petrovicová, A.
Acta Virologica 42(6): 409-411
1998
ISSN/ISBN: 0001-723X PMID: 10358748 Document Number: 496977
Cytokines have been suggested to play an important role in the pathogenesis of type I diabetes mellitus through their direct and indirect effects on the pancreatic islet cells. We studied the time course of tumour necrosis factor alpha (TNF-alpha) and glucose levels in the sera of mice infected with coxsackie B4 and A7 viruses. Two correlating peaks of TNF-alpha and glucose were found. These results suggest the involvement of TNF-alpha in the damage of the insulin producing cells and thus an immunity-related inflammatory process.
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