A distinct region of chromosome 19p13.3 associated with the sporadic form of adenoma malignum of the uterine cervix
Lee, J.Y.; Dong, S.M.; Kim, H.S.; Kim, S.Y.; Na, E.Y.; Shin, M.S.; Lee, S.H.; Park, W.S.; Kim, K.M.; Lee, Y.S.; Jang, J.J.; Yoo, N.J.
Cancer Research 58(6): 1140-1143
1998
ISSN/ISBN: 0008-5472 PMID: 9515797 Document Number: 495655
Adenoma malignum (AM) is known to be one of the malignant tumors that is commonly associated with Peutz-Jeghers syndrome. Recently, the genetic locus of Peutz-Jeghers syndrome was mapped to the telomeric region of chromosome 19p. We analyzed nine sporadic cases of AM with high-density loss of heterozygosity to study the region of chromosome 19p13.2-13.3 using eight microsatellite markers. Our deletion mapping data revealed a distinct region with 100% loss of heterozygosity frequency at marker D19S216. This result indicates that a putative tumor suppressor gene for AM is located at D19S216 on chromosomal band 19p13.3 and plays an important role in AM tumorigenesis.