Interference of myrtol standardized with inflammatory and allergic mediators
Beuscher, N.; Kietzmann, M.; Bien, E.; Champeroux, P.
Arzneimittel-Forschung 48(10): 985-989
1998
ISSN/ISBN: 0004-4172 PMID: 9825115 Document Number: 495195
Myrtol standardized (Gelomyrtol/Gelomyrtol forte) inhibits the activity of 5-lipoxygenase of human basophil and eosinophil leukocytes and the formation of leukotriene C4 as well as 1.8-cineole (eucalyptol). An increase of prostaglandins (PGE2) in mucous membranes of teat cisterns after topical administration of TPA (tetradecanoylphorbol-13-acetate) was inhibited. In vitro and in vivo studies revealed spasmolytic and broncholytic effects of Myrtol stand. After topical administration into the teat cisterns of the isolated bovine udder Myrtol stand. increased the surface temperature, comparable to effects of menthol.
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