Modulation of Anger and Aggression
Anderson; Silver
Seminars in Clinical Neuropsychiatry 3(3): 232-242
1998
ISSN/ISBN: 1084-3612 PMID: 10085211 Document Number: 495169
Traumatic brain injury commonly results in anger and aggressive behavior. The hypothalamus, limbic system, and prefrontal cortex mediate aggression, and frequently are injured during trauma. Many neurotransmitters that modulate aggressive behavior, including norepinephrine, serotonin, dopamine, and acetylcholine are affected by brain injury. The pharmacological treatment of aggression is divided into medications used for acute behavioral control, and those used for the prophylaxis of episodes. Specific recommendations are made for the choice of specific medications.