Genome shift of hepatitis e virus in Asia
Bi, S.; Zhuang, H.; Liu, C.
Zhonghua Shi Yan he Lin Chuang Bing du Xue Za Zhi 12(2): 105-106
1998
ISSN/ISBN: 1003-9279 PMID: 12515182 Document Number: 494821
Dideoxy chain termination method was applied to sequence hepatitis E virus structure gene of Asia isolates, cDNA sequence and amino acid residues were determined. The results showed that among Asia countries: Indian, Burma, China, Pakistan and Kirghiz Republic, Hepatitis E virus genome shifted within the range of 5% and amino acid residues shifted within 1% compared with Mexico isolate. Asia Hepatitis E virus isolates have limited genome shift, which suggests recombinant Hepatitis E vaccine based on Asia HEV gene might protect all HEV infection in this area.
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