Acquired lipidosis: Gaucher cells and "blue histiocytes" in chronic granulocytic leukemia, thalassemia and idiopathic thrombopenic purpura
Ursea, C.; Butoianu, E.; Munteanu, M.; Coliţă, A.; Coliţă, D.; Taigăr, S.; Nicoara, S.
Medicina Interna 25(5): 625-632
1973
ISSN/ISBN: 0025-7869 PMID: 4527023 Document Number: 4948
Bone marrow smears from 212 patients with various diseases of the blood (95 chronic granulocytic leukemia, 7 thalassemia, 15 other types of hemolytic anemia, 55 idiopathic thrombocytic purpura, 12 acute erythroleukemia, 20 acute granulocytic leukemia, 8 palycytemia vera) were studied comparatively with those obtained from 7 cases of Gaucher's disease and 50 cases of iron-defficiency anemia. Gaucher cells were found in 8 cases, histiocytes with blue granules in 16 cases and transition cells in 8 cases. The authors review the cases of diseases of the blood in which the presence of these abnormal macrophages with a lipid charge are reported by other investigators. It is assumed that the Gaucher cells and histiocytes with "acquired" blue granules arise following phagocytosis of the cellular detritus, resulting from accelerated turnover of the granullocytes and/or erythrocytes. Attention is drawn to the absence of specificity of the Gaucher cells and blue histiocytes for the Gaucher disease and, respectively, for the histiocyte syndrome.
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